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It has been linked to reductions in oxidative stress, protection of mitochondrial DNA, and modulation of gene expression related to energy balance

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466 GO and KEGG analyses based on the GSE180065 and GSE36074 datasets showed that ferroptosis-related pathways are enriched in heart failure

Major PK Uncertainties: Translational Scaling : The PK parameters (especially clearance rates and effective doses) observed in small animals do not reliably scale up to humans

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